E45 products are made by Crookes Healthcare, a division of Reckitt Benckiser, the large multinational consumer goods company based out of Slough, in England. The brand is one of the most established names in dry skin treatments in the UK market. E45 cream was first made in 1952, in response to a request for a cream that would soothe and protect the skin. It soon became apparent that it was a useful treatment for dry skin conditions.