Hyaluronic Acid (Psoriasis)

Hyaluronic acid is a major component of the extracellular matrix of most connective tissue1. It is especially abundant in the skin, where it has a protective, structure-stabilizing and shock-absorbing role2.

The body of an adult human has about 15 gram of hyaluronic acid, of which approximately half is located in the skin. Hyaluronic acid has a considerable capacity to bind water, illustrated by the fact that one single gram of hyaluronic acid can bind 6 liters of water.

Level of evidence: D

Hyaluronic acid is present in the outer skin layers (epidermis) and the layers below (dermis). In fact, it is the main substance found in dermis due to its viscoelastic properties3. Hyaluronic acid is often used as a moisturising agent due to its water binding capacity4.

HelloSkin’s experts were unable to find any scientific data or clinical trial regarding the use of hyaluronic acid in people with psoriasis. Nevertheless, hyaluronic acid has been shown beneficial in the repairing of skin injury as well as wound healing5, which is known to affect patients with psoriasis.

It should be mentioned that the moisturiser tested in both studies also contained other ingredients that are believed to benefit skin health. Therefore, the effects are not necessarily related to the content of hyaluronic acid alone.

The concentration of an ingredient is important for its efficacy, and therefore products containing the same ingredient may not necessarily have the same effect as in the studies mentioned above.

Updated: July 2017

References

1Dermatol Ther. 2006

2J Eur Acad Dermatol Venereol. 2005

3J Drugs Dermatol. 2010

4Clin Cosmet Investig Dermatol. 2013

5Wound Repair Regen. 1999